COSIE.data_preprocessing.metacell_construction_optimized
- metacell_construction_optimized(adata)[source]
Construct metacells by aggregating every 2×2 spatially adjacent grid of cells into one, using integer grid grouping for O(n) performance.
Parameters
- adataAnnData
An AnnData object with .obsm[‘spatial’] coords and .X expr. matrix.
Returns
- adata_metacellAnnData
New AnnData of metacells with averaged expression and coords, plus mapping.